Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries
نویسندگان
چکیده
منابع مشابه
Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries
Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement. In this study, we show that by characterizing the binding constants for all of the hits that arise from a screen, structure-activity relationship (...
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Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has never been applied to the discovery of short cysteine-rich peptides. We have developed the first method for the synthesis, screening, and sequ...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2014
ISSN: 2156-8952,2156-8944
DOI: 10.1021/co500154e